AOD-9604

AOD-9604 (Advanced Obesity Drug-9604) is a modified 16-amino acid fragment of human growth hormone corresponding to the C-terminal region (residues 177-191). This fragment was identified as containing the lipolytic activity of GH while lacking the diabetogenic and growth-promoting properties of the intact hormone.

Research has demonstrated AOD-9604 stimulates lipolysis (fat breakdown) and inhibits lipogenesis (fat synthesis) in adipose tissue through mechanisms that appear independent of GH receptor activation. The compound mimics the way natural GH regulates fat metabolism without the insulin-antagonizing effects that complicate GH therapy in metabolic research.

The peptide contains a disulfide bridge that creates a loop structure essential for biological activity. This constraint mimics the tertiary structure of the corresponding region in intact GH and is required for proper interaction with target proteins involved in lipid metabolism.

Beyond metabolic applications, AOD-9604 has gained research interest in the orthopedic field, with studies suggesting potential chondroprotective and cartilage-regenerative properties. This has led to investigation in osteoarthritis models, where it may support cartilage matrix synthesis and joint health.