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Semaglutide

Metabolic
Chemical Profile
Molecular Formula
C187H291N45O59
Molar Mass
4,113.58 g/mol
CAS Number
910463-68-2
Purity Standard
99%+ (HPLC Verified)
Amino Acid Sequence
Modified GLP-1 (7-37) analog with Aib8, Arg34, and C-18 fatty diacid acylation at Lys26

Overview

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that has become one of the most intensely studied peptides in metabolic research. Its structural modifications give it a significantly extended half-life compared to native GLP-1, making it particularly valuable for research into sustained receptor activation.

The compound works by mimicking the incretin hormone GLP-1, which plays a central role in glucose metabolism and appetite regulation. Research has shown semaglutide activates GLP-1 receptors in the pancreas, brain, and cardiovascular system, producing a cascade of metabolic effects.

In clinical research settings, semaglutide has demonstrated significant effects on glycemic control, body weight regulation, and cardiovascular risk markers. Its unique pharmacokinetic profile, enabled by the C-18 fatty acid modification, allows for sustained receptor engagement that closely models therapeutic dosing regimens.

Semaglutide continues to be a critical tool in metabolic research, with ongoing studies exploring its effects on non-alcoholic steatohepatitis (NASH), Alzheimer's disease, and other conditions where GLP-1 signaling may play a role.

Synthesis Overview

Semaglutide is a structurally modified analog of human GLP-1, synthesized through a combination of solid-phase peptide synthesis and selective chemical modification. The key modifications include an aminoisobutyric acid substitution at position 8 (conferring DPP-4 resistance), an arginine substitution at position 34, and a C-18 fatty diacid chain attached via a linker to lysine at position 26. This lipidation enables albumin binding, dramatically extending the compound's half-life. Post-synthesis purification via preparative HPLC ensures 99%+ purity, followed by lyophilization for stable storage.

Research Applications

  • GLP-1 receptor signaling pathway research
  • Metabolic function and glucose homeostasis studies
  • Appetite regulation and satiety mechanism investigation
  • Cardiovascular risk factor reduction research
  • Pancreatic beta-cell function studies
  • Obesity-related metabolic pathway analysis

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