Ipamorelin
Growth Hormone- Molecular Formula
- C38H49N9O5
- Molar Mass
- 711.85 g/mol
- CAS Number
- 170851-70-4
- Purity Standard
- 99%+ (HPLC Verified)
- Amino Acid Sequence
- Aib-His-D-2-Nal-D-Phe-Lys-NH2
Source Ipamorelin for Your Research
MedgePeptides offers 99%+ (hplc verified) Ipamorelin with batch-specific COAs and 1-2 day domestic shipping.
Overview
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue that activates the ghrelin/growth hormone secretagogue receptor (GHS-R1a) with remarkable selectivity. Unlike earlier generation GH secretagogues such as GHRP-6 and GHRP-2, Ipamorelin stimulates growth hormone release without significantly affecting cortisol, acetylcholine, prolactin, or aldosterone levels.
This high selectivity profile makes Ipamorelin the cleanest GH secretagogue available for research purposes, providing a tool to study GH-specific effects without the confounding variables introduced by broader hormonal modulation. Research has shown it produces dose-dependent, pulse-like GH release that closely mimics natural secretion patterns.
The compound's five-amino-acid structure, incorporating three unnatural amino acids, confers both metabolic stability and receptor specificity. Its relatively small size and favorable pharmacokinetic profile make it suitable for various research applications.
Ipamorelin is widely studied in combination with CJC-1295 (without DAC), as the dual activation of GHS-R1a and GHRHR produces a synergistic amplification of GH release that exceeds what either peptide achieves alone. This combination has become one of the most researched GH-stimulating protocols in peptide science.
Synthesis Overview
Ipamorelin is a pentapeptide synthesized via standard Fmoc solid-phase peptide synthesis incorporating several unnatural amino acid building blocks: aminoisobutyric acid (Aib), D-2-naphthylalanine (D-2-Nal), and D-phenylalanine (D-Phe). These non-standard residues require specialized coupling conditions but contribute to the peptide's exceptional receptor selectivity. Following resin cleavage, the peptide is purified to 99%+ via preparative reverse-phase HPLC. Molecular identity is confirmed by ESI-MS, and the final product is lyophilized for storage stability.
Research Applications
- Growth hormone secretagogue receptor (GHSR/GHS-R1a) binding studies
- Selective GH release without affecting cortisol or prolactin
- GH pulsatility and physiological secretion pattern research
- Bone mineral density and skeletal system studies
- Synergistic effects with GHRH analogs (e.g., CJC-1295)
- Age-related GH decline and somatopause investigation
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