TB-500

Healing & Recovery
Chemical Profile
Molecular Formula
C212H350N56O78S
Molar Mass
4,963.44 g/mol
CAS Number
77591-33-4
Purity Standard
99%+ (HPLC Verified)
Amino Acid Sequence
43-amino acid fragment of Thymosin Beta-4 (Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES)

Source TB-500 for Your Research

MedgePeptides offers 99%+ (hplc verified) TB-500 with batch-specific COAs and 1-2 day domestic shipping.

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Overview

TB-500 is a synthetic version of the naturally occurring peptide Thymosin Beta-4, a 43-amino acid protein that is found in virtually all human and animal cells. Thymosin Beta-4 is the primary G-actin sequestering peptide in the body, playing a fundamental role in cell structure, migration, and tissue repair.

Research into TB-500 has revealed its critical involvement in several key biological processes, including upregulation of actin for cell building, promotion of angiogenesis, reduction of inflammation, and facilitation of cell migration to sites of injury. These properties make it one of the most versatile healing-related peptides under investigation.

Animal studies have demonstrated TB-500's potential in accelerating dermal wound healing, promoting cardiac repair following ischemic events, and supporting recovery from musculoskeletal injuries. Its small molecular size allows it to travel through tissues efficiently, potentially reaching sites of injury that larger molecules cannot.

TB-500 is widely utilized in veterinary research, particularly in equine studies, and continues to be investigated for its broad regenerative applications in laboratory settings.

Synthesis Overview

TB-500 is produced through solid-phase peptide synthesis using standard Fmoc protection strategies. Given its relatively long sequence (43 amino acids), synthesis requires careful optimization of coupling efficiency at each step to maintain overall yield and purity. The crude product is purified via preparative reverse-phase HPLC, followed by lyophilization. Quality control includes HPLC purity assessment and electrospray ionization mass spectrometry (ESI-MS) to confirm the correct molecular weight.

Research Applications

  • Cell migration and tissue repair mechanism studies
  • Cardiac tissue recovery and repair research
  • Dermal wound healing and hair follicle studies
  • Anti-inflammatory response modulation research
  • Actin polymerization and cytoskeletal dynamics investigation
  • Corneal healing and ocular repair studies

Related Compounds