HGH Fragment 176-191

HGH Fragment 176-191 is a 16-amino acid peptide corresponding to the C-terminal region of human growth hormone, identified as containing the lipolytic (fat-burning) activity of the intact hormone. This fragment represents the same sequence as AOD-9604, differing primarily in manufacturing specifications and research applications.

The fragment retains GH's ability to stimulate lipolysis while lacking the growth-promoting and diabetogenic effects of the full hormone. Research suggests it acts through mechanisms distinct from GH receptor activation, possibly involving direct effects on adipocyte metabolism and beta-3 adrenergic signaling.

The disulfide loop formed by the two cysteine residues creates a constrained structure that mimics the tertiary fold of this region in intact GH. This structural element is essential for biological activity and must be correctly formed during synthesis.

Research applications focus on understanding the molecular basis of GH's metabolic effects separate from its anabolic properties. The fragment serves as a tool for dissecting GH pharmacology and as a candidate for metabolic research where the growth-promoting effects of GH would be unwanted.