Selank

Selank is a synthetic heptapeptide derived from the naturally occurring immunomodulatory peptide tuftsin, with a Pro-Gly-Pro extension at the C-terminus that dramatically enhances metabolic stability. Developed in Russia alongside Semax, Selank exhibits a unique combination of anxiolytic, nootropic, and immunomodulatory properties.

The anxiolytic effects of Selank are mediated through modulation of GABAergic neurotransmission, producing benzodiazepine-like anxiety reduction without the sedation, cognitive impairment, or dependence potential associated with traditional anxiolytics. Research shows Selank influences the expression of genes involved in GABA synthesis and receptor function.

Beyond anxiety research, Selank demonstrates cognitive-enhancing properties including improved memory consolidation, enhanced attention, and increased mental clarity. These effects appear to involve modulation of monoamine neurotransmitters including serotonin, dopamine, and norepinephrine.

The tuftsin-derived core sequence retains immunomodulatory activity, influencing cytokine production, lymphocyte function, and inflammatory responses. This creates a compound with both central nervous system and peripheral immune effects, useful for research into the bidirectional communication between the brain and immune system (psychoneuroimmunology).